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Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation

The asymmetric cell division of stem or progenitor cells generates daughter cells with distinct fates that balance proliferation and differentiation. Asymmetric segregation of Notch signaling regulatory protein Numb plays a crucial role in cell …

Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia

Epithelial adherens junctions (AJs) and tight junctions (TJs) undergo disassembly and reassembly during morphogenesis and pathological states. The membrane–cytoskeleton interface plays a crucial role in junctional reorganization. Protein 4.1R (4.1R), …